Role of p14ARF-HDM2-p53 axis in SOX6-mediated tumor suppression
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چکیده
منابع مشابه
Stability Adenovirus through Increased p53 Protein Translation and Enhanced Tumor Suppression by a p14ARF/p53 Bicistronic
The p53 tumor suppressor controls a cell cycle arrest and apoptosis pathway that is central to tumor suppression and often disrupted in cancer. The accumulation and activity of p53 are positively controlled by the p14 ADP p14ARF ribosylation factor (AR) tumor suppressor, and full restoration of the pathway in cancer cells may require that both p53 and p14ARF be supplied. To address this issue, ...
متن کاملEnhanced tumor suppression by a p14ARF/p53 bicistronic adenovirus through increased p53 protein translation and stability.
The p53 tumor suppressor controls a cell cycle arrest and apoptosis pathway that is central to tumor suppression and often disrupted in cancer. The accumulation and activity of p53 are positively controlled by the p14/ARF tumor suppressor and full restoration of the pathway in cancer cells may require that both p53 and p14ARF be supplied [corrected]. To address this issue, we have constructed a...
متن کاملNucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53.
The Hdm2 oncoprotein inhibits p53 functions by two means: (i) it blocks p53's transactivation activity and (ii) it targets p53 for degradation in a proteasome-dependent manner. Recent data indicate that Hdm2 shuttles between the nucleus and the cytoplasm and that the regulation of p53 levels by Hdm2 requires its nuclear export activity. Two different models are consistent with these observation...
متن کاملExpression of p14ARF overcomes tumor resistance to p53.
Tumors without p53 mutation are often resistant to p53 gene therapy. We examined the mechanism using p53-resistant A549 cells and p53-sensitive H1299 cells. We found that p53 delivered by adenovirus is poorly expressed in A549 (ARF-null) cells but efficiently expressed in H1299 cells (ARF-positive). Strong p53 expression and apoptosis can be achieved in A549 cells using a p53 mutant resistant t...
متن کاملUnmet Expectations: miR-34 Plays No Role in p53-Mediated Tumor Suppression In Vivo
In vivo modeling of tumor suppressor p53 functions and regulation has a history of unexpected and even enigmatic outcomes [1], despite the status of p53 as the most frequently mutated gene or dysfunctional pathway in human cancers [2,3]. Beginning with the surprising viability of the first mice deleted for Trp53 [4,5], various hypotheses of compensation, cell type–specificity, stimulus-dependen...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2015
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2015.234